Human endogenous retrovirus K in cancer: a potential biomarker and immunotherapeutic target
G Curty, JL Marston, M de Mulder Rougvie, FE Leal… - Viruses, 2020 - mdpi.com
In diseases where epigenetic mechanisms are changed, such as cancer, many genes show
altered gene expression and inhibited genes become activated. Human endogenous …
altered gene expression and inhibited genes become activated. Human endogenous …
Ancient adversary–HERV-K (HML-2) in cancer
E Dervan, DD Bhattacharyya, JD McAuliffe… - Frontiers in …, 2021 - frontiersin.org
Human endogenous retroviruses (HERV), ancient integrations of exogenous viruses, make
up 8% of our genome. Long thought of as mere vestigial genetic elements, evidence is now …
up 8% of our genome. Long thought of as mere vestigial genetic elements, evidence is now …
[HTML][HTML] Activation of HERV-K (HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3
VP Nair, H Liu, G Ciceri, J Jungverdorben, G Frishman… - Cell stem cell, 2021 - cell.com
The biological function and disease association of human endogenous retroviruses
(HERVs) are largely elusive. HERV-K (HML-2) has been associated with neurotoxicity, but …
(HERVs) are largely elusive. HERV-K (HML-2) has been associated with neurotoxicity, but …
Human endogenous retroviruses in cancer: Expression, regulation and function
Y Gao, XF Yu, T Chen - Oncology Letters, 2021 - spandidos-publications.com
Human endogenous retroviruses (HERVs) are the remnants of ancient retroviruses that
infected human germline cells and became integrated into the human genome millions of …
infected human germline cells and became integrated into the human genome millions of …
A systematic review of expression and immunogenicity of human endogenous retroviral proteins in cancer and discussion of therapeutic approaches
MD Müller, PJ Holst, KN Nielsen - International Journal of Molecular …, 2022 - mdpi.com
Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections that
have become fixed in the human genome. While HERV genes are typically silenced in …
have become fixed in the human genome. While HERV genes are typically silenced in …
Ribosomal profiling of human endogenous retroviruses in healthy tissues
Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of
ancient retroviral infections that make up roughly 8% of the human genome. Our …
ancient retroviral infections that make up roughly 8% of the human genome. Our …
Application of third-generation sequencing in cancer research
Z Chen, X He - Medical Review, 2021 - degruyter.com
In the past several years, nanopore sequencing technology from Oxford Nanopore
Technologies (ONT) and single-molecule real-time (SMRT) sequencing technology from …
Technologies (ONT) and single-molecule real-time (SMRT) sequencing technology from …
Identification of differentially expressed human endogenous retrovirus families in human leukemia and lymphoma cell lines and stem cells
K Engel, L Wieland, A Krüger, I Volkmer, H Cynis… - Frontiers in …, 2021 - frontiersin.org
Endogenous retroviruses (ERVs) are becoming more and more relevant in cancer research
and might be potential targets. The oncogenic potential of human ERVs (HERVs) has been …
and might be potential targets. The oncogenic potential of human ERVs (HERVs) has been …
Limitations of current high-throughput sequencing technologies lead to biased expression estimates of endogenous retroviral elements
K Kitsou, A Katzourakis… - NAR Genomics and …, 2024 - academic.oup.com
Human endogenous retroviruses (HERVs), the remnants of ancient germline retroviral
integrations, comprise almost 8% of the human genome. The elucidation of their biological …
integrations, comprise almost 8% of the human genome. The elucidation of their biological …
Mechanistic regulation of HERV activation in tumors and implications for translational research in oncology
EA Cherkasova, L Chen, RW Childs - Frontiers in Cellular and …, 2024 - frontiersin.org
Transcription of distinct loci of human endogenous retroviruses (HERVs) and in some cases,
translation of these transcripts have been consistently observed in many types of cancer. It is …
translation of these transcripts have been consistently observed in many types of cancer. It is …