Compared with traditional drug therapy, nanomedicines exhibit intriguing biological features
to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review …

Abstract Nanocrystals have contributed to exciting improvements in the delivery of poorly
water-soluble drugs. The biological and intracellular fates of nanocrystals are currently …

Due to its poor prognosis and propensity for metastasizing, colon cancer, a frequent cancer
of the gastrointestinal system, has a high morbidity and mortality rate. However, the harsh …

Numerous literatures have shown the advantages of Pickering emulsion (PE) for the delivery
of bioactive ingredients in the fields of food, medicine, and cosmetics, among others. On this …

Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs in
the Biopharmaceutical Classification System (BCS) due to the absorption of the intact …

Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …

Objectives Bacterial infections are a noteworthy global health concern that necessitates the
development of new strategies to enhance the potency and efficacy of antibiotics. Rifaximin …

Introduction Although flavonoid compounds exhibit various pharmacological activities, their
clinical applications are restricted by low oral bioavailability owing to their poor solubility …

Despite the safety and convenience of oral administration, poorly water-soluble drugs
compromise absorption and bioavailability. These drugs can exhibit low dissolution rates …

To improve the oral absorption and anticancer efficacy of the BCS-IV drug etoposide (ETO),
oral nanocrystal-loaded lipid carriers (Lipo@ NCs) were developed in this study by …