Allostery is largely associated with conformational and functional transitions in individual
proteins. This concept can be extended to consider the impact of conformational …

Dopamine (DA) is one of the major neurotransmitters and participates in a number of
functions such as motor coordination, emotions, memory, reward mechanism …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E 2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

The intracellular signalling kinases Akt/protein kinase B (Akt), protein kinase A (PKA) and
adenosine monophosphate‐activated protein kinase (AMPK) are phosphorylated in …

We report the molecular and cytogenetic characterization of a novel variant of acute
promyelocytic leukemia (APL). The bone marrow showed 88% hypergranular …

Prostaglandin (PG) signaling regulates a wide variety of physiological and pathological
processes, including body temperature, cardiovascular homeostasis, reproduction, and …

PKA anchoring proteins (AKAPs) optimize the efficiency of cAMP signaling by clustering
interacting partners. Recently, AKAP79 has been reported to directly bind to adenylyl …

The cyclic AMP-dependent protein kinase A signaling pathway plays a major role in
regulating plant infection by the rice blast fungus Magnaporthe oryzae. Here, we report the …

Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase
(PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9 …