Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

Many neuropsychiatric and neurodevelopmental disorders commonly share genetic risk
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …

Background The proteome is a major source of therapeutic targets. We conducted a
proteome-wide Mendelian randomization (MR) study to identify candidate protein markers …

In brain, signaling mediated by cell adhesion molecules defines the identity and functional
properties of synapses. The specificity of presynaptic and postsynaptic interactions that is …

Major depressive disorder (MDD) is a prevalent and serious mental disorder with high rates
of suicide and disability. However, the underlying pathogenesis of MDD is complicated and …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by the loss of upper and lower motor neurons, which eventually may lead to …

The amyloid precursor protein (APP), one key player in Alzheimer's disease (AD), is
extensively processed by different proteases. This leads to the generation of diverging …

A single-molecule three-dimensional (3D) structure is essential for understanding the
thermal vibrations and dynamics as well as the conformational changes during the chemical …

Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …

Ubiquitous expression of GABA type A receptors (GABAAR) in the central nervous system
establishes their central role in coordinating most aspects of neural function and …