Advances in engineering human tissue models

CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …

Toward building the neuromuscular junction: in vitro models to study synaptogenesis and neurodegeneration

A Natarajan, A Sethumadhavan, UM Krishnan - ACS omega, 2019 - ACS Publications
The neuromuscular junction (NMJ) is a unique, specialized chemical synapse that plays a
crucial role in transmitting and amplifying information from spinal motor neurons to skeletal …

Neuromuscular disease modeling on a chip

JW Santoso, ML McCain - Disease models & mechanisms, 2020 - journals.biologists.com
Organs-on-chips are broadly defined as microfabricated surfaces or devices designed to
engineer cells into microscale tissues with native-like features and then extract …

Combinatorial biophysical cue sensor array for controlling neural stem cell fate

JM Lee, WS Kang, KG Lee, HY Cho, B Conley… - Biosensors and …, 2020 - Elsevier
Biophysical cues, such as electrical stimulus, mechanical feature, and surface topography,
enable the control of neural stem cell (NSC) differentiation and neurite outgrowth. However …

In vitro models of neuromuscular junctions and their potential for novel drug discovery and development

OF Vila, Y Qu, G Vunjak-Novakovic - Expert opinion on drug …, 2020 - Taylor & Francis
ABSTRACT Introduction: Neuromuscular Junctions (NMJs) are the synapses between motor
neurons and skeletal muscle fibers, and they are responsible for voluntary motor function …

Creating stem cell‐derived neuromuscular junctions in vitro

SM Luttrell, AST Smith, DL Mack - Muscle & Nerve, 2021 - Wiley Online Library
Recent development of novel therapies has improved mobility and quality of life for people
suffering from inheritable neuromuscular disorders. Despite this progress, the majority of …

Modeling the neuromuscular junction in vitro: an approach to study neuromuscular junction disorders

MJ Castellanos‐Montiel, I Velasco… - Annals of the New …, 2021 - Wiley Online Library
The neuromuscular junction (NMJ) is a specialized structure that works as an interface to
translate the action potential of the presynaptic motor neuron (MN) in the contraction of the …

Optimization of Application-Driven Development of In Vitro Neuromuscular Junction Models

JB Strickland, K Davis-Anderson… - … Engineering Part B …, 2022 - liebertpub.com
Neuromuscular junctions (NMJs) are specialized synapses responsible for signal
transduction between motor neurons (MNs) and skeletal muscle tissue. Malfunction at this …

Challenges and Future Prospects on 3D in-vitro Modeling of the Neuromuscular Circuit

M Badiola-Mateos, A Hervera, JA Del Rio… - … in bioengineering and …, 2018 - frontiersin.org
Movement of skeletal-muscle fibers is generated by the coordinated action of several cells
taking part within the locomotion circuit (motoneurons, sensory-neurons, Schwann cells …

Voltage-gated calcium channels as potential therapeutic targets in migraine

JG Chichorro, E Gambeta, DF Baggio, GW Zamponi - The Journal of Pain, 2024 - Elsevier
Migraine is a complex and highly incapacitating neurological disorder that affects around
15% of the general population with greater incidence in women, often at the most productive …