Over the past decade, researchers in the pharmaceutical industry and academia have made
retrospective analyses of successful drug campaigns in order to establish" rules" to guide …

Drug discovery has classically targeted the active sites of enzymes or ligand-binding sites of
receptors and ion channels. In an attempt to improve selectivity of drug candidates …

Cet article explique que le Canada n'a pas vécu la periode d'après guerre de la même façon
que des autres pays industrialisés. L'état providence canadien et les politiques …

The spike (S) glycoprotein of the avian gammacoronavirus infectious bronchitis virus (IBV) is
comprised of two subunits (S1 and S2), has a role in virulence in vivo, and is responsible for …

The DNA sequencing technology developed by Frederick Sanger in the 1970s established
genomics as the basis of comparative genetics. The recent invention of next-generation …

Protein‐protein interactions are an important phenomenon in biological processes and
functions. We used the manually curated non‐redundant dataset of 118 phycocyanin …

Here we review the use of informatics in structural interactomics, with particular emphasis on
understanding interfacial contacts in the development of novel therapeutics and the …

The failure of the pharmaceutical industry to increase the delivery of new drugs into the
market is driving a re-assessment of practices and methods in drug discovery and …