Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a
range of neurodegenerative diseases that are collectively referred to as tauopathies …

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy—a class of disorders in
which the tau protein forms insoluble inclusions in the brain—that is characterized by motor …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

A pathway from the natively unfolded microtubule-associated protein Tau to a highly
structured amyloid fibril underlies human Tauopathies. This ordered assembly causes …

The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and
filamentous tau protein is at the centre of many human neurodegenerative diseases …

Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder
linked to repetitive traumatic brain injury (TBI) and characterized by deposition of …

Progressive supranuclear palsy (PSP) is a movement disorder with prominent tau
neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most …

Parkinson disease (PD), once considered as a prototype of a sporadic disease, is now
known to be considerably affected by various genetic factors, which interact with …