The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies

E Quertemont, S Tambour, E Tirelli - Progress in neurobiology, 2005 - Elsevier
Acetaldehyde has long been suggested to be involved in a number of ethanol's
pharmacological and behavioral effects, such as its reinforcing, aversive, sedative, amnesic …

The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake

ME Quintanilla, Y Israel, A Sapag… - Addiction Biology, 2006 - Wiley Online Library
Ethanol non‐drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar
colony have been selectively bred at the University of Chile for over 70 generations. Two …

Ethanol metabolism in rat brain homogenates by a catalase-H2O2 system

CMG Aragon, F Rogan, Z Amit - Biochemical pharmacology, 1992 - Elsevier
Homogenates of perfused rat brains incubated in the presence of ethanol (50–100 mM) and
glucose (10 mM) were found to oxidize ethanol to acetaldehyde. The addition of glucose …

Enzymatic production of acetaldehyde from ethanol in rat brain tissue

K Gill, JF Menez, D Lucas… - Alcoholism: Clinical and …, 1992 - Wiley Online Library
The capacity for the brain to produce acetaldehyde (AcHO) from ethanol was determined in
rat brain homogenates. Rat brains were perfused with saline‐heparin solution and …

Ethanol metabolism in the brain

SM ZIMATKIN, RA DEITRICH - Addiction biology, 1997 - Wiley Online Library
Acetaldehyde is suspected of being involved in the central mechanism of central nervous
system depression and addiction to ethanol, but in contrast to ethanol, it can not penetrate …

Catalase mediates acetaldehyde formation from ethanol in fetal and neonatal rat brain

R Hamby‐Mason, JJ Chen, S Schenker… - Alcoholism: Clinical …, 1997 - Wiley Online Library
Fetal ethanol (E) exposure has well documented deleterious effects on brain development,
yet it is uncertain if the neurotoxicity of maternal E consumption is generated by E itself, by its …

Brain metabolism of ethanol and alcoholism: an update

L Hipolito, MJ Sanchez, A Polache… - Current drug …, 2007 - ingentaconnect.com
It has long been suggested that some of the neuropharmacological, neurochemical and
behavioural effects of ethanol are mediated by its first metabolite, acetaldehyde. In spite of …

Catalase and the production of brain acetaldehyde: a possible mediator of the psychopharmacological effects of ethanol

BR SMITH, CMG Aragon, Z AMIT - Addiction biology, 1997 - Wiley Online Library
This review represents an attempt to assess the available data on the role of catalase in the
mediation of the behavioral actions of ethanol and the regulation of voluntary ethanol …

Studies on ethanol‐brain catalase interaction: evidence for central ethanol oxidation

CMG Aragon, Z Amit, LM Stotland - Alcoholism: Clinical and …, 1991 - Wiley Online Library
The purpose of the present investigation was to further study the relationship between
ethanol and brain catalase in vivo. Rats were pretreated intraperitoneally (ip) with varying …

Effects of 3-amino-1, 2, 4-triazole on brain catalase in the mediation of ethanol consumption in mice

UM Koechling, Z Amit - Alcohol, 1994 - Elsevier
Research has suggested that catalase plays a role in mediating ethanol's
psychopharmacological effects. It has been shown that acatalasemic (C3H-A) mice differing …