Resolvins and protectins in inflammation resolution

CN Serhan, NA Petasis - Chemical reviews, 2011 - ACS Publications
The critical role of inflammatory processes in health and disease has long been recognized,
1 yet the detailed molecular mechanisms and biological events that regulate the progression …

NSAIDs and cancer resolution: new paradigms beyond cyclooxygenase

OR Kolawole, K Kashfi - International journal of molecular sciences, 2022 - mdpi.com
Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

CN Serhan - Annu. Rev. Immunol., 2007 - annualreviews.org
Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered …

Are Alkyne Reductions Chemo-, Regio-, and Stereoselective Enough To Provide Pure (Z)-Olefins in Polyfunctionalized Bioactive Molecules?

C Oger, L Balas, T Durand, JM Galano - Chemical reviews, 2013 - ACS Publications
Many biologically active molecules incorporate carbon− carbon double bond (s) with well-
defined configurations (E or Z), such as β-carotene, 1 polyene antifungal drugs, 2, 3 …

Anti-inflammatory drugs in the 21st century

KD Rainsford - Inflammation in the pathogenesis of chronic diseases …, 2007 - Springer
Historically, anti-inflammatory drugs had their origins in the serendipitous discovery of
certain plants and their extracts being applied for the relief of pain, fever and inflammation …

Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins

M Spite, CN Serhan - Circulation research, 2010 - Am Heart Assoc
The resolution of acute inflammation is a process that allows for inflamed tissues to return to
homeostasis. Resolution was held to be a passive process, a concept now overturned with …

Endogenous pro‐resolving and anti‐inflammatory lipid mediators: a new pharmacologic genus

CN Serhan, N Chiang - British journal of pharmacology, 2008 - Wiley Online Library
Complete resolution of an acute inflammatory response and its return to homeostasis are
essential for healthy tissues. Here, we overview ongoing efforts to characterize cellular and …

Severe asthma in adults: what are the important questions?

P Chanez, SE Wenzel, GP Anderson, JM Anto… - Journal of Allergy and …, 2007 - Elsevier
The term severe refractory asthma (SRA) in adults applies to patients who remain difficult to
control despite extensive re-evaluation of diagnosis and management following an …

The protectin family of specialized pro-resolving mediators: potent immunoresolvents enabling innovative approaches to target obesity and diabetes

TV Hansen, A Vik, CN Serhan - Frontiers in pharmacology, 2019 - frontiersin.org
A western type diet and lifestyle play an important role in the development of chronic
diseases, yet little insight into the precise cellular and biomolecular mechanisms has …

FPR2/ALXR agonists and the resolution of inflammation

O Corminboeuf, X Leroy - Journal of medicinal chemistry, 2015 - ACS Publications
The resolution of inflammation (RoI), once believed to be a passive process, has lately been
shown to be an active and delicately orchestrated process. During the resolution phase of …