Progranulin Facilitates Corneal Repair Through Dual Mechanisms of Inflammation Suppression and Regeneration Promotion

D Yan, Y Zhang, Y Huang, W Ouyang - Inflammation, 2024 - Springer
The cornea serves as a vital protective barrier for the eye; however, it is prone to injury and
damage that can disrupt corneal epithelium and nerves, triggering inflammation. Therefore …

Tumor necrosis factor regulates leukocyte recruitment but not bacterial persistence during Staphylococcus aureus craniotomy infection

Z Van Roy, T Kielian - Journal of Neuroinflammation, 2024 - Springer
Background Craniotomy is a common neurosurgery used to treat intracranial pathologies.
Nearly 5% of the 14 million craniotomies performed worldwide each year become infected …

Advances in the Understanding of the Correlation Between Neuroinflammation and Microglia in Alzheimer's Disease

H Yan, W Wang, T Cui, Y Shao, M Li… - ImmunoTargets and …, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a fatal neurodegenerative disease with a subtle and progressive
onset and is the most common type of dementia. However, its etiology and pathogenesis …

Enhanced immunomodulation and periodontal regeneration efficacy of subgingivally delivered progranulin‐loaded hydrogel as an adjunct to non‐surgical treatment …

W Liu, A Song, Y Wu, P Gong, J Zhao… - Journal of Clinical …, 2024 - Wiley Online Library
Aim To evaluate the effect of subgingival delivery of progranulin (PGRN)/gelatin
methacryloyl (GelMA) complex as an adjunct to scaling and root planing (SRP) on an …

Smart coating by thermo-sensitive Pluronic F-127 for enhanced corneal healing via delivery of biological macromolecule progranulin

D Yan, W Ouyang, J Lin, Z Liu - International Journal of Biological …, 2023 - Elsevier
As a leading cause of vision impairment and blindness, corneal alkali burns lead to long-
term visual deterioration or even permanent visual impairment while effective treatment …

[HTML][HTML] Progranulin and Vaspin as Potential Novel Markers in the Etiology of Type 1 Diabetes in Children

K Jakubek-Kipa, S Galiniak, A Mazur - Medicina, 2024 - mdpi.com
Background and Objectives: Diabetes is a significant health problem, prompting the search
for new therapeutic strategies. Recently, researchers have focused on identifying novel …

Animal granulins: In the GRN scheme of things

CR Bowhay, PC Hanington - Developmental & Comparative Immunology, 2024 - Elsevier
Granulins are conserved in nearly all metazoans, with an intriguing loss in insects. These
pleiotropic peptides are involved in numerous physiological and pathological processes yet …

Maternal organokines throughout pregnancy as predictors of neonatal anthropometric characteristics and adiposity

J Valencia-Ortega, V Galicia-Hernández… - Frontiers in …, 2024 - frontiersin.org
Aims To evaluate the relation between maternal concentrations of progranulin (PGRN),
adipocyte fatty acid-binding protein (AFABP), brain-derived neurotrophic factor (BDNF), and …

iTRAQ-Based Serum Proteomic Analysis Reveals Multifactorial Cellular Function Impairment and Aggravated Systematic Inflammation in Drug-free Obsessive …

M Deng, X Li, D Shi, Q Fan, H Zhang… - ACS Chemical …, 2024 - ACS Publications
Obsessive-compulsive disorder (OCD) is a debilitating mental disorder with obvious
difficulties in treatment. Its pathogenesis has not been fully elucidated. Further …

Plasma Kallistatin and Progranulin as Predictive Biomarkers of Intraamniotic Inflammation, Microbial Invasion of the Amniotic Cavity, and Composite Neonatal …

KH Park, KN Lee, I Cho, MJ Lee… - American Journal of …, 2024 - Wiley Online Library
Problem To explore the clinical utility of nine inflammatory immune‐, adhesion‐, and
extracellular matrix‐related mediators in the plasma for predicting intraamniotic inflammation …