Unleashing the power of immune checkpoints: post-translational modification of novel molecules and clinical applications

J Wang, Y Wang, X Jiang, M Xu, M Wang, R Wang… - Cancer Letters, 2024 - Elsevier
Immune checkpoint molecules play a pivotal role in the initiation, regulation, and termination
of immune responses. Tumor cells exploit these checkpoints to dampen immune cell …

The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer

Y Hou, B Lin, T Xu, J Jiang, S Luo, W Chen… - Nature …, 2024 - nature.com
Neurotransmitters are key modulators in neuro-immune circuits and have been linked to
tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor …

Modulating macrophage-mediated programmed cell removal: An attractive strategy for cancer therapy

Z Li, B Han, M Qi, Y Li, Y Duan, Y Yao - Biochimica et Biophysica Acta (BBA …, 2024 - Elsevier
Macrophage-mediated programmed cell removal (PrCR) is crucial for the identification and
elimination of needless cells that maintain tissue homeostasis. The efficacy of PrCR …

SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism

Y Sakano, K Sakano, BP Hurrell… - Cellular & Molecular …, 2024 - nature.com
Group-2 innate lymphoid cells (ILC2) are part of a growing family of innate lymphocytes
known for their crucial role in both the development and exacerbation of allergic asthma …

Bioengineer mesenchymal stem cell for treatment of glioma by IL‐12 mediated microenvironment reprogramming and nCD47‐SLAMF7 mediated phagocytosis …

M Li, L Lu, Q Xiao, AA Maalim, B Nie, Y Liu… - …, 2024 - Wiley Online Library
High expression of cellular self‐activated immunosuppressive molecules and extensive
infiltration of suppressive immune cells in the tumor microenvironment are the main factors …

Remodeling the hepatic immune microenvironment and demolishing T cell traps to enhance immunotherapy efficacy in liver metastasis

Z Luo, M Jiang, N Cheng, X Zhao, H Liu, S Wang… - Journal of Controlled …, 2024 - Elsevier
Immune checkpoint inhibitors (ICIs) exhibit compromised therapeutic efficacy in many
patients with advanced cancers, particularly those with liver metastases. Much of this …

Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy

Q Zhang, G Kuang, L Wang, L Fan, Y Zhou… - Journal of …, 2024 - Springer
Microcarrier is a promising drug delivery system demonstrating significant value in treating
cancers. One of the main goals is to devise microcarriers with ingenious structures and …

Impact and potential value of immunosenescence on solid gastrointestinal tumors

T Zhang, R Wen, H Fan, Y Yu, H Jia, Z Peng… - Frontiers in …, 2024 - frontiersin.org
Solid gastrointestinal tumors often respond poorly to immunotherapy for the complex tumor
microenvironment (TME), which is exacerbated by immune system alterations …

Fibroblast activation protein constitutes a novel target of chimeric antigen receptor T‐cell therapy in solid tumors

S Meng, T Hara, Y Miura, H Ishii - Cancer Science, 2024 - Wiley Online Library
With recent advances in tumor immunotherapy, chimeric antigen receptor T (CAR‐T) cell
therapy has achieved unprecedented success in several hematologic tumors, significantly …

Decoding changes in tumor‐infiltrating leukocytes through dynamic experimental models and single‐cell technologies

CYC Lee, MR Clatworthy… - Immunology and Cell …, 2024 - Wiley Online Library
The ability to characterize immune cells and explore the molecular interactions that govern
their functions has never been greater, fueled in recent years by the revolutionary advance …