Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and
pose major challenges for societies with rapidly aging populations. Human genetics studies …

Maintaining a healthy proteome is fundamental for the survival of all organisms. Integral to
this are Hsp90 and Hsp70, molecular chaperones that together facilitate the folding …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Heat shock protein 90 (Hsp90) is a molecular chaperone involved in the maturation of a
plethora of substrates (“clients”), including protein kinases, transcription factors, and E3 …

Tissue-resident macrophages (TRMs) and dendritic cells (DCs) are highly heterogeneous
and essential for immunity, tissue regeneration, and homeostasis maintenance. Here, we …

The toxic accumulation of misfolded proteins as inclusions, fibrils, or aggregates is a
hallmark of many neurodegenerative diseases. However, how molecular chaperones, such …

Abstract Heat shock protein (HSP) 90, an important component of the molecular chaperone
network, is closely concerned with cellular signaling pathways and stress response by …

Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones,
which participate in protein folding and maturation in response to stresses or high …