Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

The licensed drug rapamycin has potential to be repurposed for geroprotection. A key
challenge is to avoid adverse side effects from continuous dosing. Here we show that …

Development is tightly connected to aging, but whether pharmacologically targeting
development can extend life remains unknown. Here, we subjected genetically diverse …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor
(DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a …

Pharmacological attenuation of mTOR presents a promising route for delay of age-related
disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin …

Chromatin architecture is a fundamental mediator of genome function. Fasting is a major
environmental cue across the animal kingdom, yet how it impacts three-dimensional (3D) …

Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in
diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are …