Neuronal action potentials or spikes provide a long-range, noise-resistant means of
communication between neurons. As point processes single spikes contain little information …

Half a century since their discovery by Llinás and colleagues, dendritic spikes have been
observed in various neurons in different brain regions, from the neocortex and cerebellum to …

Imaging neurons and neural circuits over large volumes at high speed and subcellular
resolution is a difficult task. Incorporating a Bessel focus module into a two-photon …

This review article addresses the function of the layers of the cerebral cortex. We develop
the perspective that cortical layering needs to be understood in terms of its functional …

Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations,
reflecting neural population activity, involve the reactivation of learning-related neurons and …

NMDA receptors (NMDARs) play a critical role in excitatory synaptic transmission, plasticity
and in several forms of learning and memory. In addition, NMDAR dysfunction is believed to …

Migraine is a complex brain disorder, characterized by attacks of unilateral headache and
global dysfunction in multisensory information processing, whose underlying cellular and …

Migraine is a common but poorly understood sensory circuit disorder. Mouse models of
familial hemiplegic migraine (FHM, a rare monogenic form of migraine with aura) show …

Cortical wiring relies on guidepost cells and activity-dependent processes that are thought to
act sequentially. Here, we show that the construction of layer 1 (L1), a main site of top-down …