Articular cartilage defects are prevalent and are potentially involved in the initiation of
osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents …

Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a
growing trend with the increasing life span. OA is the most prevalent joint condition …

Introduction: Osteoarthritis (OA) is the most prevalent chronic joint disease. Its key feature is
a progressive articular cartilage loss. Gene therapy for OA aims at delivering gene-based …

Recombinant adeno-associated viral (rAAV) vectors are clinically adapted gene transfer
vectors for direct human cartilage regenerative medicine. Their appropriate use in patients is …

The development of efficient and safe gene transfer vectors capable of achieving
appropriate levels of therapeutic gene expression in a target is one of the most challenging …

The aim of this work was to investigate, for the first time, the possibility of using
supramolecular polypseudorotaxane gels as scaffolds that can durably deliver rAAV vectors …

Background: The delivery of therapeutic genes in sites of articular cartilage lesions using
non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate …

Scaffold-guided gene transfer offers strong systems to develop noninvasive convenient
therapeutic options for the treatment of articular cartilage defects, especially when targeting …

Administration of therapeutic gene sequences coding for chondrogenic and
chondroreparative factors in bone marrow aspirates using the clinically adapted …

Damage to the articular cartilage is an important, prevalent, and unsolved clinical issue for
the orthopaedic surgeon. This review summarizes innovative basic research approaches …