Intervertebral disc degeneration is a major cause of low back pain. Despite its long history
and large socio-economical impact in western societies, the initiation and progress of disc …

BACKGROUND CONTEXT: Destruction of extracellular matrix (ECM) leads to intervertebral
disc degeneration (IDD), which underlies many spine-related disorders. Matrix …

INTERVENTIONS-MANUAL THERAPY: Clinicians should consider utilizing thrust
manipulative procedures to reduce pain and disability in patients with mobility deficits and …

Strategies for the biological repair of intervertebral discs derive from the premise that disc
degeneration results from impaired cellular activity and, therefore, that these structures can …

Objective Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear
which individuals develop it. The authors examined the contribution of genetic factors …

Degeneration of the intervertebral discs, a process characterized by a cascade of cellular,
biochemical, structural and functional changes, is strongly implicated as a cause of low back …

Lumbar discectomy is the surgical procedure most frequently performed for patients
suffering from low back pain and sciatica. Disc herniation as a consequence of degenerative …

BACKGROUND CONTEXT: Low back pain is prevalent in the United States. At the present
time, no large longitudinal study is available characterizing the incidence of this condition in …

BACKGROUND CONTEXT: Disc degeneration (DD) is a multifaceted chronic process that
alters the structure and function of the intervertebral discs and can lead to painful conditions …

BACKGROUND CONTEXT: For patients with low back pain, fear-avoidance beliefs (FABs)
represent cognitions and emotions that underpin concerns and fears about the potential for …