Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

Our understanding of the networks of genes and protein functions involved in Alcohol Use
Disorder (AUD) remains incomplete, as do the mechanisms by which these networks lead to …

Mice with a mutation in the Clock gene (ClockΔ19) exhibit increased preference for stimulant
rewards and sucrose. They also have an increase in dopaminergic activity in the ventral …

Recent advances in neurogenetics have highlighted Drosophila melanogaste r as an
exciting model to study neural circuit dynamics and complex behavior. Automated tracking …

Alcohol tolerance is a simple form of behavioural and neural plasticity that occurs with the
first drink. Neural plasticity in tolerance is likely a substrate for longer term adaptations that …

Alcohol abuse is a significant public health problem. While considerable research has
shown that alcohol use affects sleep, little is known about the role of sleep deprivation in …

Alcohol abuse is a widespread and serious problem. Understanding the factors that
influence the likelihood of abuse is important for the development of effective therapies …

The neural circuitry and molecules that control the rewarding properties of food and drugs of
abuse appear to partially overlap in the mammalian brain. This has raised questions about …

Background G protein signaling pathways are key neuromodulatory mechanisms for
behaviors and neurological functions that affect the impact of ethanol (EtOH) on locomotion …

Neurons integrate excitatory and inhibitory signals to produce their outputs, but the role of
input timing in this integration remains poorly understood. Motion detection is a paradigmatic …