Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …

Immunopolymorphism is considered as an important aspect behind the resistance or
susceptibility of the host to an infectious disease. Over the years, researchers have explored …

Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

Despite a century of research on complex traits in humans, the relative importance and
specific nature of the influences of genes and environment on human traits remain …

Genome-wide association studies have identified many noncoding variants associated with
common diseases and traits. We show that these variants are concentrated in regulatory …

Forensic DNA Phenotyping refers to the prediction of appearance traits of unknown sample
donors, or unknown deceased (missing) persons, directly from biological materials found at …

Obtaining genome-wide genotype data from a set of individuals is the first step in many
genomic studies, including genome-wide association and genomic selection. All genotyping …

More than 90% of the compounds that enter clinical trials fail to demonstrate sufficient safety
and efficacy to gain regulatory approval. Most of this failure is due to the limited predictive …

Genotype imputation is a statistical technique that is often used to increase the power and
resolution of genetic association studies. Imputation methods work by using haplotype …

Abstract Type 2 diabetes (T2D) is the result of interaction between environmental factors and
a strong hereditary component. We review the heritability of T2D as well as the history of …