Neuronal identity control by terminal selectors in worms, flies, and chordates

O Hobert, P Kratsios - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Terminal selector control terminal steps of neuronal identity acquisition.•Terminal
selectors establish and maintain neuron type-specific identity features.•Terminal selectors …

Terminal selectors of neuronal identity

O Hobert - Current topics in developmental biology, 2016 - Elsevier
The analysis of the developmental programs that define many different neuron types in the
nematode Caenorhabditis elegans has revealed common themes in how distinct terminal …

Whole-animal connectomes of both Caenorhabditis elegans sexes

SJ Cook, TA Jarrell, CA Brittin, Y Wang, AE Bloniarz… - Nature, 2019 - nature.com
Abstract Knowledge of connectivity in the nervous system is essential to understanding its
function. Here we describe connectomes for both adult sexes of the nematode …

A cellular and regulatory map of the cholinergic nervous system of C. elegans

L Pereira, P Kratsios, E Serrano-Saiz, H Sheftel… - Elife, 2015 - elifesciences.org
Nervous system maps are of critical importance for understanding how nervous systems
develop and function. We systematically map here all cholinergic neuron types in the male …

Phenotypic convergence: distinct transcription factors regulate common terminal features

N Konstantinides, K Kapuralin, C Fadil, L Barboza… - Cell, 2018 - cell.com
Transcription factors regulate the molecular, morphological, and physiological
characteristics of neurons and generate their impressive cell-type diversity. To gain insight …

A cellular and regulatory map of the GABAergic nervous system of C. elegans

M Gendrel, EG Atlas, O Hobert - Elife, 2016 - elifesciences.org
Neurotransmitter maps are important complements to anatomical maps and represent an
invaluable resource to understand nervous system function and development. We report …

Exploring the neurogenic differentiation of human dental pulp stem cells

AA Al-Maswary, M O'Reilly, AP Holmes, AD Walmsley… - PLoS …, 2022 - journals.plos.org
Human dental pulp stem cells (hDPSCs) have increasingly gained interest as a potential
therapy for nerve regeneration in medicine and dentistry, however their neurogenic potential …

Regulatory logic of pan-neuronal gene expression in C. elegans

N Stefanakis, I Carrera, O Hobert - Neuron, 2015 - cell.com
While neuronal cell types display an astounding degree of phenotypic diversity, most if not
all neuron types share a core panel of terminal features. However, little is known about how …

Synaptogenesis: unmasking molecular mechanisms using Caenorhabditis elegans

K Mizumoto, Y Jin, JL Bessereau - Genetics, 2023 - academic.oup.com
The nematode Caenorhabditis elegans is a research model organism particularly suited to
the mechanistic understanding of synapse genesis in the nervous system. Armed with …

A map of terminal regulators of neuronal identity in Caenorhabditis elegans

O Hobert - Wiley Interdisciplinary Reviews: Developmental …, 2016 - Wiley Online Library
Our present day understanding of nervous system development is an amalgam of insights
gained from studying different aspects and stages of nervous system development in a …