Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Covering: 1928–2021 Ginkgo biloba L. is one of the most distinctive plants to have emerged
on earth and has no close living relatives. Owing to its phylogenetic divergence from other …

The chemical analysis and quality control of Ginkgo leaves, extracts, phytopharmaceuticals
and some herbal supplements is comprehensively reviewed. The review is an update of a …

The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

A common strategy of metabolic engineering is to increase the endogenous supply of
precursor metabolites to improve pathway productivity. The ability to further enhance …

Ts65Dn mice, a model for Down syndrome, have excessive inhibition in the dentate gyrus, a
condition that could compromise synaptic plasticity and mnemonic processing. We show that …

Amyloid-β (Aβ) toxicity has been postulated to initiate synaptic loss and subsequent
neuronal degeneration seen in Alzheimer's disease (AD). We previously demonstrated that …

Anxiety disorders are chronic and functionally disabling conditions with high psychological
stress, characterised by cognitive symptoms of excessive worry and focus difficulties and …

The convulsant alkaloid bicuculline continues to be investigated more than 40 years after
the first publication of its action as an antagonist of receptors for the inhibitory …

GABAA receptor channels are ubiquitous in the mammalian central nervous system
mediating fast inhibitory neurotransmission by becoming permeant to chloride ions in …