Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of
diseases with different clinical manifestations including cutaneous, mucocutaneous and …

Highlights•Visceral leishmaniasis is a complicated infectious disease.•Emerging resistance
is one of the main complications in treatment visceral leishmaniasis.•A comprehensive …

Mammalian target of rapamycin (m TOR) is a central regulator of growth and immunity of
host cells. It's involvement in cancer and tuberculosis is well documented but least explored …

Visceral leishmaniasis (VL) is one of the most neglected tropical diseases for which no
vaccine exists. In spite of extensive efforts, no successful vaccine is available against this …

Molecular therapy refers to targeted therapies based on molecules which have been
intelligently directed towards specific biomolecular structures and include small molecule …

Besides their medical relevance, Leishmania is an adequate model for studying post-
transcriptional mechanisms of gene expression. In this microorganism, mRNA degradation …

Background Endoplasmic reticulum (ER) stress generated unfolded stress response (UPR)
is a basic survival mechanism which protects cell under unfavourable conditions …

Leishmaniasis is a serious world health problem and its current therapies have several
limitations demanding to develop novel therapeutics for this disease. The present study aims …

Leishmaniasis comprises of a wide variety of diseases, caused by protozoan parasite
belonging to the genus Leishmania. Leishmania parasites undergo different types of stress …

Abstract Adenosine 3', 5'‐cyclic monophosphate (cAMP) is a stress sensor molecule that
transduces the cellular signal when Leishmania donovani moves from insect vector to …