Precision medicine in the era of artificial intelligence: implications in chronic disease management

M Subramanian, A Wojtusciszyn, L Favre… - Journal of translational …, 2020 - Springer
Aberrant metabolism is the root cause of several serious health issues, creating a huge
burden to health and leading to diminished life expectancy. A dysregulated metabolism …

Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics

JC Park, SH Im - Experimental & molecular medicine, 2020 - nature.com
Considerable evidence points to the critical role of the gut microbiota in physiology and
disease. The administration of live microbes as a therapeutic modality is increasingly being …

The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Y Zou, S Wang, H Zhang, Y Gu, H Chen… - Medicinal Research …, 2024 - Wiley Online Library
Over the past decade, colorectal cancer has reported a higher incidence in younger adults
and a lower mortality rate. Recently, the influence of the intestinal flora in the initiation …

Manipulations of the gut microbiome alter chemotherapy-induced inflammation and behavioral side effects in female mice

CV Grant, BR Loman, MT Bailey, LM Pyter - Brain, behavior, and immunity, 2021 - Elsevier
Chemotherapy treatment is associated with acute behavioral side effects (fatigue, anorexia)
that significantly reduce patient quality of life and are dose-limiting, thereby increasing …

Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls

CE Gheorghe, NL Ritz, JA Martin, HR Wardill… - Gut …, 2021 - Taylor & Francis
In recent years, studies investigating the role of the gut microbiota in health and diseases
have increased enormously–making it essential to deepen and question the research …

Host Genetic Determinants of the Microbiome Across Animals: From Caenorhabditis elegans to Cattle

EP Ryu, ER Davenport - Annual review of animal biosciences, 2022 - annualreviews.org
Animals harbor diverse communities of microbes within their gastrointestinal tracts.
Phylogenetic relationship, diet, gut morphology, host physiology, and ecology all influence …

Anti-Tick Microbiota Vaccine Impacts Ixodes ricinus Performance during Feeding

L Mateos-Hernández, D Obregón, J Maye, J Borneres… - Vaccines, 2020 - mdpi.com
The tick microbiota is a highly complex ensemble of interacting microorganisms. Keystone
taxa, with a central role in the microbial networks, support the stability and fitness of the …

The gut microbiome and substance use disorder

JT Russell, Y Zhou, GM Weinstock… - Frontiers in …, 2021 - frontiersin.org
Substance use disorders (SUDs) remain a significant public health challenge, affecting tens
of millions of individuals worldwide each year. Often comorbid with other psychiatric …

[HTML][HTML] Improving natural product research translation: From source to clinical trial

BC Sorkin, AJ Kuszak, G Bloss… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
While great interest in health effects of natural product (NP) including dietary supplements
and foods persists, promising preclinical NP research is not consistently translating into …

Intestinal dysbiosis in, and enteral bacterial therapies for, systemic autoimmune diseases

E Marietta, AK Mangalam, V Taneja… - Frontiers in …, 2020 - frontiersin.org
Recent studies have shown that a number of common autoimmune diseases have
perturbations of their intestinal microbiome (dysbiosis). These include: Celiac Disease …