In eukaryotic organisms, the orthologs of the DEAD-box RNA helicase Ded1p from yeast
and DDX3 from human form a well-defined subfamily that is characterized by high sequence …

The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …

Natural killer/T-cell lymphoma (NKTCL) is a malignant proliferation of CD56+ and cytoCD3+
lymphocytes with aggressive clinical course, which is prevalent in Asian and South …

Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated
and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box …

Medulloblastomas are the most common malignant brain tumours in children. Identifying
and understanding the genetic events that drive these tumours is critical for the development …

Intellectual disability (ID) affects approximately 1%–3% of humans with a gender bias toward
males. Previous studies have identified mutations in more than 100 genes on the X …

Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten
genome integrity. Using Xenopus egg extracts, we previously showed that replication fork …

Here, we have characterized a step in translation initiation of viral and cellular mRNAs that
contain RNA secondary structures immediately at the vicinity of their m7GTP cap. This is …

Triplex DNA structures, formed when a third DNA strand wraps around the major groove of
DNA, are key molecular regulators and genomic threats. However, the regulatory network …

The worldwide SARS-CoV-2 outbreak poses a serious challenge to human societies and
economies. SARS-CoV-2 proteins orchestrate complex pathogenic mechanisms that …