Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

Over 100 types of chemical modifications have been identified in cellular RNAs. While the
5′ cap modification and the poly (A) tail of eukaryotic mRNA play key roles in regulation …

Nanopore RNA sequencing shows promise as a method for discriminating and identifying
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …

The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

During ribosome biogenesis, ribosomal RNAs acquire various chemical modifications that
ensure the fidelity of translation, and dysregulation of the modification processes can cause …

Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis
and have been implicated in the dysregulation of protein synthesis, as is found in cancer …

To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …

Ribosomes are complex ribozymes that interpret genetic information by translating
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …