The diversity and breadth of cancer cell fatty acid metabolism
Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …
biomass synthesis while maintaining redox balance and cellular homeostasis. These …
Targeting phospholipid metabolism in cancer
All cancers tested so far display abnormal choline and ethanolamine phospholipid
metabolism, which has been detected with numerous magnetic resonance spectroscopy …
metabolism, which has been detected with numerous magnetic resonance spectroscopy …
Choline metabolism-based molecular diagnosis of cancer: an update
Abnormal choline metabolism continues to be identified in multiple cancers. Molecular
causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine …
causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine …
New insights into the molecular and epigenetic effects of antitumor Pt (IV)-valproic acid conjugates in human ovarian cancer cells
V Novohradsky, L Zerzankova, J Stepankova… - Biochemical …, 2015 - Elsevier
Substitutionally inert Pt (IV) prodrugs, combining bioactive axial ligands with Pt (IV)
derivatives of antitumor Pt (II) compounds, represent a new generation of anticancer drugs …
derivatives of antitumor Pt (II) compounds, represent a new generation of anticancer drugs …
Choline kinase α mediates interactions between the epidermal growth factor receptor and mechanistic target of rapamycin complex 2 in hepatocellular carcinoma cells …
XM Lin, L Hu, J Gu, RY Wang, L Li, J Tang, BH Zhang… - Gastroenterology, 2017 - Elsevier
Background & Aims Choline kinase α (CHKA) catalyzes conversion of choline to
phosphocholine and can contribute to carcinogenesis. Little is known about the role of …
phosphocholine and can contribute to carcinogenesis. Little is known about the role of …
Choline kinase alpha—Putting the ChoK-hold on tumor metabolism
It is well established that lipid metabolism is drastically altered during tumor development
and response to therapy. Choline kinase alpha (ChoKα) is a key mediator of these changes …
and response to therapy. Choline kinase alpha (ChoKα) is a key mediator of these changes …
2-hydroxyglutarate-mediated autophagy of the endoplasmic reticulum leads to an unusual downregulation of phospholipid biosynthesis in mutant IDH1 gliomas
Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In
particular, cancer cells upregulate synthesis of the membrane phospholipids …
particular, cancer cells upregulate synthesis of the membrane phospholipids …
Investigating the effects of PFOA accumulation and depuration on specific phospholipids in zebrafish through imaging mass spectrometry
Q Shi, Z Wan, S Lu, C Fang, C Yan… - … Science: Processes & …, 2024 - pubs.rsc.org
Perfluorooctanoic acid (PFOA) is an emerging persistent organic pollutant. Exposure to
PFOA was observed to have a correlation with the expression levels of phospholipids …
PFOA was observed to have a correlation with the expression levels of phospholipids …
Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease
that develops relatively symptom-free and is therefore advanced at the time of diagnosis …
that develops relatively symptom-free and is therefore advanced at the time of diagnosis …
[HTML][HTML] Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines
J Ma, X Guo, S Zhang, H Liu, J Lu… - Molecular …, 2015 - spandidos-publications.com
Histone deacetylase (HDAC)‑mediated epigenetic modification plays crucial roles in
numerous biological processes, including cell cycle regulation, cell proliferation and …
numerous biological processes, including cell cycle regulation, cell proliferation and …