Human skin forms a protective barrier against the external environment and is our first line of
defense against toxic, solar, and pathogenic insults. Our skin also defines our outward …

Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

The skin provides both a physical barrier and an immunologic barrier to external threats. The
protective machinery of the skin has evolved to provide situation-specific responses to …

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …

Abstract Background Psoriasis impacts 1–3% of the world's population and is characterized
by hyper-proliferation of keratinocytes and increased inflammation. At the molecular level …

Background There is increasing evidence of the key role that the gut microbiota plays in
inflammatory diseases. Objectives To identify differences in the faecal microbial composition …

With advancement in human microbiome research, an increasing number of scientific
evidences have endorsed the key role of both gut and skin microbiota in the pathogenesis of …

Skin colonization by Staphylococcus aureus and its relative abundance is associated with
atopic dermatitis (AD) disease severity and treatment response. Low levels of antimicrobial …

Autoimmune disorders derive from genetic, stochastic, and environmental factors that all
together interact in genetically predisposed individuals. The impact of an imbalanced gut …

Abstract Background and Objective Immunotherapy could change the complex host-
microbial interactions. We aimed to investigate the dynamics of gut microbiome in response …