Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

The ongoing search for therapeutic interventions in Alzheimer disease (AD) has highlighted
the complexity of this condition and the need for additional biomarkers, beyond amyloid-β …

Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …

In this review article we have consolidated the imaging literature of patients with
schizophrenia across the full spectrum of modalities in radiology including computed …

Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population
worldwide. Despite the major unmet clinical need, no new medications for the treatment of …

Schizophrenia is a severe neuropsychiatric disease that is associated with neurobiological
alterations in multiple brain regions and peripheral organs. Negative symptoms and …

A potential pathophysiological mechanism of cognitive difficulties in schizophrenia is a
dysregulated cholinergic system. Particularly, the cholinergic basal forebrain nuclei (BFCN) …