Early in development, placental and marsupial mammals harbouring at least two X
chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …

Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive
myeloid malignancies recognized as a distinct category owing to their unique combination of …

Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the
development of hematological malignancies (HM) and cardiovascular diseases. Previous …

Background The lesions of Langerhans'-cell histiocytosis (histiocytosis X), a proliferative
histiocytic disorder of unknown cause, contain histiocytes similar in phenotype to dendritic …

The utility of X-inactivation based clonality assays for evaluation of human neoplasia is well-
documented. However, excessive Lyonization is a potential limitation of these assays …

G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …

The incidence of skewed X-inactivation in normal women is controversial, with up to 10-fold
differences being reported by different authors. In order to clarify this issue, we have …

More frequent skewing of X‐chromosome inactivation patterns (XCIPs) occurs in the white
blood cells of elderly females; this study was performed to determine whether this occurs in …

Studies of X chromosome inactivation patterns are central to many aspects of our
understanding of the pathogenesis of haematological malignancies. In patients with …