Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Organocatalytic Asymmetric Epoxidation and Aziridination of Olefins and Their Synthetic
Applications | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

Type I modular polyketide synthases are homodimeric multidomain assembly line enzymes
that synthesize a variety of polyketide natural products by performing polyketide chain …

Cyclopropane, epoxide, and aziridine groups are three-membered ring structural elements
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …

The structural features of polycyclic polyether natural products can, in some cases, be traced
to their biosynthetic origin. However in case that are less well understood, only biosynthetic …

Here we report a transcription factor decoy strategy for targeted activation of eight large
silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging …

Covering: 2002 to September 2009 In recent years, a number of gene clusters involved in
the biosynthesis of polyketide compounds have been characterized and the genes have …

Pnictogen‐bonding catalysis and supramolecular σ‐hole catalysis in general is currently
being introduced as the non‐covalent counterpart of covalent Lewis acid catalysis. With …

Polycyclic polyether natural products have fascinated chemists and biologists alike owing to
their useful biological activity, highly complex structure and intriguing biosynthetic …

Tetrahydropyrans (THPs) are common structural motifs found in natural products and
synthetic therapeutic molecules. In Nature these 6-membered oxygen heterocycles are often …