Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes
develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin …

Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell
function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta …

Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver
disease worldwide (about 25% of the general population) and 3–5% of patients develop non …

Pancreatic beta (β) cell dysfunction results in compromised insulin release and, thus, failed
regulation of blood glucose levels. This forms the backbone of the development of diabetes …

Alterations in endoplasmic reticulum (ER) calcium (Ca 2+) levels diminish insulin secretion
and reduce β-cell survival in both major forms of diabetes. The mechanisms responsible for …

A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

Abstract The cytoplasmic Ca 2+ concentration ([Ca 2+] cyt) regulates a vast number of
cellular functions, including insulin secretion from beta cells. The major physiological insulin …

Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-
associated diseases. However, there are no scalable approaches to comprehensively …