High‐throughput sequencing for biology and medicine

WW Soon, M Hariharan, MP Snyder - Molecular systems biology, 2013 - embopress.org
Advances in genome sequencing have progressed at a rapid pace, with increased
throughput accompanied by plunging costs. But these advances go far beyond faster and …

[HTML][HTML] Circulating tumour cells: the evolving concept and the inadequacy of their enrichment by EpCAM-based methodology for basic and clinical cancer research

PK Grover, AG Cummins, TJ Price… - Annals of …, 2014 - Elsevier
Increasing evidence suggests that circulating tumour cells (CTCs) are responsible for
metastatic relapse and this has fuelled interest in their detection and quantification. Although …

Early-stage lung cancer diagnosis by deep learning-based spectroscopic analysis of circulating exosomes

H Shin, S Oh, S Hong, M Kang, D Kang, Y Ji, BH Choi… - ACS …, 2020 - ACS Publications
Lung cancer has a high mortality rate, but an early diagnosis can contribute to a favorable
prognosis. A liquid biopsy that captures and detects tumor-related biomarkers in body fluids …

[HTML][HTML] A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire

N Saucedo-Zeni, S Mewes… - International …, 2012 - spandidos-publications.com
The isolation of circulating tumor cells (CTCs) from the blood of patients afflicted with solid
malignant tumors becomes increasingly important as it may serve as a 'liquid biopsy'with the …

Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation

M Ivanov, A Baranova, T Butler, P Spellman, V Mileyko - BMC genomics, 2015 - Springer
Background The assessment of cell-free circulating DNA fragments, also known as a" liquid
biopsy" of the patient's plasma, is an important source for the discovery and subsequent non …

Key molecular mechanisms in lung cancer invasion and metastasis: a comprehensive review

F Perlikos, KJ Harrington, KN Syrigos - Critical reviews in oncology …, 2013 - Elsevier
Lung cancer remains one of the most common and malignant cancers worldwide. It is most
often diagnosed at late stages, when it has already presented local invasion and distal …

Update on the types and usage of liquid biopsies in the clinical setting: a systematic review

B Arneth - BMC cancer, 2018 - Springer
Background This systematic review aimed to gather evidence from research on the current
state of liquid biopsy in medical practice, specifically focusing on mutation detection and …

Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

TR Samatov, AG Tonevitsky, U Schumacher - Molecular cancer, 2013 - Springer
Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and
metastases formation during malignant progression. This review focuses on transcriptional …

Capturing cancer: emerging microfluidic technologies for the capture and characterization of circulating tumor cells

W Qian, Y Zhang, W Chen - Small, 2015 - Wiley Online Library
Circulating tumor cells (CTCs) escape from primary or metastatic lesions and enter into
circulation, carrying significant information of cancer progression and metastasis. Capture of …

[HTML][HTML] Current progress and mechanisms of bone metastasis in lung cancer: a narrative review

S Wu, Y Pan, Y Mao, Y Chen, Y He - Translational lung cancer …, 2021 - ncbi.nlm.nih.gov
Lung cancer is a kind of malignant tumor with rapid progression and poor prognosis. Distant
metastasis has been the main cause of mortality among lung cancer patients. Bone is one of …