The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …

The importance of the renin angiotensin aldosterone system in cardiovascular physiology
and pathophysiology has been well described whereas the detailed molecular mechanisms …

Vascular remodeling refers to changes in the size, contraction, distribution, and flow rate of
blood vessels and even changes in vascular function. Vascular remodeling can cause …

Vulnerable plaque rupture is the main trigger of most acute cardiovascular events. But the
underlying mechanisms responsible for the transition from stable to vulnerable plaque …

Abstracts Atrial fibrosis, the hallmark of structural remodeling associated with atrial fibrillation
(AF), is characterized by abnormal proliferation of atrial fibroblasts and excessive deposition …

Background Oxidative stress plays critical pathophysiological roles in vascular remodeling-
related cardiovascular diseases, including hypertension, atherosclerosis, and restenosis …

Cardiovascular calcification is a significant public health issue whose pathophysiology is not
fully understood. NOR-1 regulates critical processes in cardiovascular remodeling, but its …

Objective—Vascular smooth muscle cells (VSMCs) phenotype modulation is critical for the
resolution of vascular injury. Genetic and pharmacological inhibition of PI3Kγ …