Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Monocytes and macrophages in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …
Immune and inflammatory mechanisms of abdominal aortic aneurysm
AC Marquez-Sanchez, EK Koltsova - Frontiers in immunology, 2022 - frontiersin.org
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …
mediated infiltration and a destruction of the aortic wall during AAA development plays …
AT1 receptor signaling pathways in the cardiovascular system
The importance of the renin angiotensin aldosterone system in cardiovascular physiology
and pathophysiology has been well described whereas the detailed molecular mechanisms …
and pathophysiology has been well described whereas the detailed molecular mechanisms …
Mechanism of Hypoxia‐Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling
X Huang, EE Akgün, K Mehmood… - BioMed research …, 2022 - Wiley Online Library
Vascular remodeling refers to changes in the size, contraction, distribution, and flow rate of
blood vessels and even changes in vascular function. Vascular remodeling can cause …
blood vessels and even changes in vascular function. Vascular remodeling can cause …
NR1D1 Deletion Induces Rupture‐Prone Vulnerable Plaques by Regulating Macrophage Pyroptosis via the NF‐κB/NLRP3 Inflammasome Pathway
Z Wu, F Liao, G Luo, Y Qian, X He, W Xu… - Oxidative Medicine …, 2021 - Wiley Online Library
Vulnerable plaque rupture is the main trigger of most acute cardiovascular events. But the
underlying mechanisms responsible for the transition from stable to vulnerable plaque …
underlying mechanisms responsible for the transition from stable to vulnerable plaque …
The crucial role of activin A/ALK4 pathway in the pathogenesis of Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation
Q Wang, Y Yu, P Zhang, Y Chen, C Li, J Chen… - Basic Research in …, 2017 - Springer
Abstracts Atrial fibrosis, the hallmark of structural remodeling associated with atrial fibrillation
(AF), is characterized by abnormal proliferation of atrial fibroblasts and excessive deposition …
(AF), is characterized by abnormal proliferation of atrial fibroblasts and excessive deposition …
Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of β-catenin and regulation of its stability
Z Cai, Z Wang, R Yuan, M Cui, Y Lao, Y Wang, P Nie… - …, 2021 - thelancet.com
Background Oxidative stress plays critical pathophysiological roles in vascular remodeling-
related cardiovascular diseases, including hypertension, atherosclerosis, and restenosis …
related cardiovascular diseases, including hypertension, atherosclerosis, and restenosis …
[HTML][HTML] Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification
C Ballester-Servera, L Cañes, J Alonso… - Translational …, 2024 - Elsevier
Cardiovascular calcification is a significant public health issue whose pathophysiology is not
fully understood. NOR-1 regulates critical processes in cardiovascular remodeling, but its …
fully understood. NOR-1 regulates critical processes in cardiovascular remodeling, but its …
PI3Kγ (Phosphoinositide 3-Kinase γ) regulates vascular smooth muscle cell phenotypic modulation and neointimal formation through CREB (Cyclic AMP-Response …
Q Yu, W Li, R Jin, S Yu, D Xie, X Zheng… - … , and vascular biology, 2019 - Am Heart Assoc
Objective—Vascular smooth muscle cells (VSMCs) phenotype modulation is critical for the
resolution of vascular injury. Genetic and pharmacological inhibition of PI3Kγ …
resolution of vascular injury. Genetic and pharmacological inhibition of PI3Kγ …