Contrast-induced nephropathy (CIN) has long been observed in both experimental and
clinical studies. However, recent observational studies have questioned the prevalence and …

Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently
worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in …

Background Organ crosstalk can be defined as the complex and mutual biological
communication between distant organs mediated by signaling factors. Normally, crosstalk …

Background Acute lung injury caused by renal ischemia–reperfusion is one of the leading
causes of acute kidney injury-related death. Dexmedetomidine, an α 2-adrenergic agonist …

Acute kidney injury (AKI) is a systemic disease associated with widespread effects on distant
organs, including the heart. Normal cardiac function is dependent on constant ATP …

Clinical evidence has indicated a possible link between renal injury and remote liver injury.
We investigated whether extracellular histone mediates remote hepatic damage after renal …

Fibroblast growth factor 23 (FGF23), a hormone generally derived from bone, is important in
phosphate and vitamin D homeostasis. In acute kidney injury (AKI) patients, high-circulating …

Ischemia-reperfusion (IR) is a common risk factor that causes acute kidney injury (AKI). AKI
is associated with dysfunction of other organs also known as distant organ injury. The liver …

Klotho-and beclin 1-driven autophagy extends life. We examined the role of beclin 1 in
modifying acute kidney injury (AKI) and whether beclin 1 mediates Klotho's known …

Acute kidney injury (AKI) has been a global health epidemic problem with soaring incidence,
increased long-term risks for multiple comorbidities and mortality, as well as elevated …