Accurate and rapid detection of tumors is of great importance for interrogating the molecular
basis of cancer pathogenesis, preventing the onset of complications, and implementing a …

Recognition of the importance of angiogenesis to tumor growth and metastasis has led to
efforts to develop new drugs that are targeted to angiogenic vasculature. Clinical trials of …

The integrin αvβ3 plays an important role in angiogenesis and tumor metastasis. It is
expressed on activated endothelial cells as well as some tumor cells. Therefore it is a …

Mosaicing of confocal images enables observation of nuclear morphology in large areas of
tissue. An application of interest is rapid detection of basal cell carcinomas (BCCs) in skin …

Optical molecular imaging in small animals harnesses the power of highly specific and
biocompatible contrast agents for drug development and disease research,,,,,,. However, the …

Diffuse optical tomography (DOT) poses a typical ill-posed inverse problem with a limited
number of measurements and inherently low spatial resolution. In this paper, we propose a …

We present a fast scanning fluorescence optical tomography system for imaging the kinetics
of probe distributions through out the whole body of small animals. Configured in a plane …

This paper provides an overview of optical imaging methods commonly applied to basic
research applications. Optical imaging is well suited for non-clinical use, since it can exploit …

Doxorubicin (DOX) is an anthracycline antibiotic widely used in cancer chemotherapy. Its
use is limited by cardiac toxicity and drug resistance. Hyperthermia can aid the functionality …

Near-infrared (NIR) diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI)
show promise as noninvasive clinical techniques for breast cancer screening and diagnosis …