The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves
as a key conduit between growth signals and the metabolic processes underlying cell …

The proteome of cells is synthesized by ribosomes, complex ribonucleoproteins that in
eukaryotes contain 79–80 proteins and four ribosomal RNAs (rRNAs) more than 5,400 …

Abstract S6 kinases (S6Ks) are mechanistic target of rapamycin substrates that participate in
cell growth control. S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins …

Ribosome biogenesis is critical for cells to generate the ribosomes they need for protein
synthesis in order to survive, grow and proliferate. It is a complex process, involving the …

The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …

The production of ribosomes is an energy-intensive process owing to the intricacy of these
massive macromolecular machines. Each human ribosome contains 80 ribosomal proteins …

Akt is a central player in the signal transduction pathways activated in response to many
growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

Cell growth is a highly regulated, plastic process. Its control involves balancing positive
regulation of anabolic processes with negative regulation of catabolic processes. Although …

The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes
stress to which an unfolded protein response is activated to render cell survival or apoptosis …