Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that …

Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …

Longevity and aging are two sides of the same coin, as they both derive from the interaction
between genetic and environmental factors. Aging is a complex, dynamic biological process …

Non-resolving inflammation drives the development of clinically dangerous atherosclerotic
lesions by promoting sustained plaque inflammation, large necrotic cores, thin fibrous caps …

The critical role of inflammatory processes in health and disease has long been recognized,
1 yet the detailed molecular mechanisms and biological events that regulate the progression …

Active resolution of acute inflammation is a previously unrecognized interface between
innate and adaptive immunity. Once thought to be a passive process, the resolution of …

Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that
fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered …