BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing
evidence has shown that reprogrammed metabolism may play a critical role in the …

Cancer cell metabolism is heavily influenced by microenvironmental factors, including
nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential …

Highlights•The first step in metastasis is invasion of tumor cells into the stroma.•Stromal
collagen is dramatically remodeled during tumor progression.•Tumor cells can invade the …

Alteration of tissue mechanical properties is a physical hallmark of solid tumors including
gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here …

Solid stress and tissue stiffness affect tumour growth, invasion, metastasis and treatment.
Unlike stiffness, which can be precisely mapped in tumours, the measurement of solid …

Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary
hypertension (PH). However, the mechanisms by which biophysical properties of the …

Risk factors for pancreatic ductal adenocarcinoma (PDAC) progression after surgery are
unclear, and additional prognostic factors are needed to inform treatment regimens and …

Cells respond to both chemical and mechanical cues present within their microenvironment.
Various mechanical signals are detected by and transmitted to the cells through …

Simple Summary This review depicts the principal mechanisms involved in the process of
stromal desmoplasia characterizing pancreatic ductal adenocarcinoma (PDAC). The aim of …