Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy
syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted …

Dental caries and periodontitis account for a vast burden of morbidity and healthcare
spending, yet their genetic basis remains largely uncharacterized. Here, we identify self …

Non-syndromic tooth agenesis (NSTA) is one of the most common dental developmental
malformations affected by genetic factors predominantly. Among all 36 candidate genes …

Background: Tooth agenesis, the congenital absence of one or more teeth, can be
diagnosed in children in the first decade of life. Tooth agenesis is a phenotypic feature of …

Despite much progress in understanding the genetics of syndromic tooth agenesis (TA), the
causes of the most common, isolated TA remain elusive. Recent studies have identified …

Abstract Introduction Orofacial clefts (OFCs) are common craniofacial birth defects with
heterogeneous phenotype and etiology. Geneticists have applied nearly every available …

Determining genotype–phenotype correlations in patients with hypodontia is important for
understanding disease pathogenesis, although only a few studies have elucidated it. We …

Tooth number anomalies, including hyperdontia and hypodontia, are common congenital
dental problems in the dental clinic. The precise number of teeth in a dentition is essential …

The Wnt pathway is involved in several processes essential for bone development and
homeostasis. For proper functioning, the Wnt pathway is tightly regulated by numerous …