Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular
signaling, differentiation, and survival. In this review, we discuss the types of ROS, their …

Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

The non-essential amino acid serine supports several metabolic processes that are crucial
for the growth and survival of proliferating cells, including protein, amino acid and …

The non-essential amino acids serine and glycine are used in multiple anabolic processes
that support cancer cell growth and proliferation (reviewed in ref.). While some cancer cells …

An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …

Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Despite
recent advances in the molecular genetics of CRC, poor treatment outcomes highlight the …

Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities,
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …

The reversible oxidation-reduction homeostasis mechanism functions as a specific signal
transduction system, eliciting related physiological responses. Disruptions to redox …