A pharmacological update of ellagic acid

JL Ríos, RM Giner, M Marín, MC Recio - Planta medica, 2018 - thieme-connect.com
Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is
present either in free form or as part of more complex molecules (ellagitannins), which can …

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

J Zhang, D Duan, ZL Song, T Liu… - Medicinal Research …, 2021 - Wiley Online Library
Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

[HTML][HTML] Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

W Liu, X Cui, Y Zhong, R Ma, B Liu, Y Xia - Pharmacological research, 2023 - Elsevier
Polyphenols, also known as phenolic compounds, are chemical substances containing
aromatic rings as well as at least two hydroxyl groups. Natural phenolic compounds exist …

[HTML][HTML] The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art

G Lu, X Wang, M Cheng, S Wang, K Ma - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Ellagic acid (EA) is a kind of polyphenol compound extracted from a variety of herbs, such as
paeoniae paeoniae, raspberry, Chebule, walnut kernel, myrrh, loquat leaf, pomegranate …

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming

Z Zhang, TE Li, M Chen, D Xu, Y Zhu, BY Hu… - British journal of …, 2020 - nature.com
Background Mitochondrial dynamics plays an important role in tumour progression.
However, how these dynamics integrate tumour metabolism in hepatocellular carcinoma …

Phenolic compounds cannabidiol, curcumin and quercetin cause mitochondrial dysfunction and suppress acute lymphoblastic leukemia cells

M Olivas-Aguirre, L Torres-López, I Pottosin… - International Journal of …, 2020 - mdpi.com
Anticancer activity of different phenols is documented, but underlying mechanisms remain
elusive. Recently, we have shown that cannabidiol kills the cells of acute lymphoblastic …

Ellagic acid: a logical lead for drug development?

A Shakeri, MR Zirak, A Sahebkar - Current pharmaceutical …, 2018 - ingentaconnect.com
Background: Naturally occurring polyphenols are the subject of increasing attention due to
their potent antioxidant activity and their marked effects on the prevention of various …

Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases

AM Roushandeh, Y Kuwahara, MH Roudkenar - Cytotechnology, 2019 - Springer
Mitochondria are attractive cellular organelles which are so interesting in both basic and
clinical research, especially after it was found that they were arisen as a bacterial intruder in …

Selective cytotoxicity of luteolin and kaempferol on cancerous hepatocytes obtained from rat model of hepatocellular carcinoma: involvement of ROS-mediated …

E Seydi, A Salimi, HR Rasekh, Z Mohsenifar… - Nutrition and …, 2018 - Taylor & Francis
To evaluate the cytotoxicity effects of luteolin (LUT) and kaempferol (KAE) via reactive
oxygen species (ROS) mediated mitochondrial targeting on hepatocytes obtained from the …

[HTML][HTML] SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum

R Liu, P Cao, A Ren, S Wang, T Yang, T Zhu, L Shi… - Redox Biology, 2018 - Elsevier
Ganoderma lucidum has high commercial value because it produces many active
compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to …