A hypothesis implicating dopamine in depression was proposed over 15 years ago
(Randrup et al 1975). The identification of multiple new subtypes of dopamine receptors and …

The dopamine hypothesis of schizophrenia and the emphasis on other neurotransmitters,
most notably norepinephirne, serotonin, and acetylcholine, in the pathogenesis of …

Background There is evidence that medications or vitamins that increase the levels of brain
catecholamines and protect against oxidative damage may reduce the neuronal damage …

In a clinical trial that is still in progress, we studied the ability of deprenyl and tocopherol,
antioxidative agents that act through complementary mechanisms, to delay the onset of …

Parkinson's disease, known also as striatal dopamine deficiency syndrome, is a
degenerative disorder of the central nervous system characterized by akinesia, muscular …

The effects of MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine), a neurotoxin that
produces the symptoms of Parkinson's disease, can be fully prevented in experimental …

• DATATOP (Deprenylandtocopherolantioxidativetherap…) is a placebo-controlled clinical
trial designed to test the hypothesis that long-term treatment of patients with early …

Since the identification of 2‐phenylethylamine (β‐phenylethylamine; PE) as a biogenic
amine, there has been much discussion about what role, if any, it may have in the CNS …

Daily sc injection of (−) deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused
a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain …

Long-term experiments on male rats revealed that better performers in the mating test are
better learners in the shuttle box and the more active animals live significantly longer than …