Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

In monoaminergic neurons, the vesicular transporters and the plasma membrane
transporters operate in a relay. Amphetamine and its congeners target this relay to elicit their …

The dopamine transporter (DAT) transports extracellular dopamine into the intracellular
space contributing to the regulation of dopamine neurotransmission. A reduction of DAT …

Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

Clathrin-mediated endocytosis oversees the constitutive packaging of selected membrane
cargoes into transport vesicles that fuse with early endosomes. The process is responsive to …

Drug transporter proteins are critical to the distribution of a wide range of endogenous
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …

Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

From the moment of cotranslational insertion into the lipid bilayer of the endoplasmic
reticulum (ER), newly synthesized integral membrane proteins are subject to a complex …

Modification by Lys63-linked ubiquitin (UbK63) chains is the second most abundant form of
ubiquitylation. In addition to their role in DNA repair or kinase activation, UbK63 chains …