There are three main mechanisms of neuronal cell death which may act separately or
cooperatively to cause neurodegeneration. This lethal triplet of metabolic compromise …

The different types of striatal neuron show a range of vulnerabilities to a variety of insults.
This can be clearly seen in Huntington's disease where a well mapped pattern of …

The effects of methamphetamine (METH) on pro-oxidant processes and on the production of
reactive oxygen species were examined in vivo in the rat brain. The presence of oxidative …

Dysfunctions of Ca 2+ homeostasis and of mitochondria have been studied in immortalized
striatal cells from a commonly used Huntington disease mouse model. Transcriptional …

We examined the effects of methamphetamine (METH) on monoaminergic (ie dopamine and
serotonin) axonal markers and glial cell activation in the rat brain. Our findings indicate that …

Huntington's disease (HD), an inherited neurodegenerative disorder, results from an
abnormal polyglutamine extension in the N-terminal region of the huntingtin protein. This …

The neurotoxic actions of methamphetamine (METH) may be mediated in part by reactive
oxygen species (ROS). Methamphetamine administration leads to increases in ROS …

The effects of minocycline on behavioral changes and neurotoxicity in the dopaminergic
neurons induced by the administration of methamphetamine (METH) were studied …

Hyperthermia exacerbates and hypothermia attenuates methamphetamine (METH)-induced
dopamine (DA) neurotoxicity. The mechanisms underlying these temperature effects are …

Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by
chorea, psychiatric disturbances, and dementia. The striatum is the primary site of neuronal …