The splicing of mRNA requires a group of essential factors known as SR proteins, which
participate in the maturation of the spliceosome. These proteins contain one or two RNA …

Topoisomerase I (Top1) catalyzes two transesterification reactions: single-strand DNA
cleavage and religation that are normally coupled for the relaxation of DNA supercoiling in …

Expression of most RNA polymerase II transcripts requires the coordinated execution of
transcription, splicing, and 3′ processing. We have previously shown that upon …

Serine‐arginine protein kinases (SPRKs) constitute a relatively novel subfamily of serine‐
threonine kinases that specifically phosphorylate serine residues residing in serine …

Alternative splicing (AS) is one of the key processes involved in the regulation of gene
expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the …

The production of mRNAs in all living organisms is an extremely complex process that
includes multiple catalytic activities such as transcription, capping, splicing, polyadenylation …

Topoisomerase I is a ubiquitous and essential enzyme in multicellular organisms. It is
involved in multiple DNA transactions including DNA replication, transcription, chromosome …

Summary Serine/arginine-rich (SR) proteins are important players in RNA metabolism and
are extensively phosphorylated at serine residues in RS repeats. Here, we show that …

Human DNA topoisomerase I is the target of camptothecins, which have been recently
introduced in the clinic for cancer chemotherapy. The discovery of novel noncamptothecin …

The prevalence of alternative splicing as a target for alterations leading to human genetic
disorders makes it highly relevant for therapy. Here we have used in vitro splicing reactions …