Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …

Brain macrophage populations include parenchymal microglia, border-associated
macrophages, and recruited monocyte-derived cells; together, they control brain …

The developmental and molecular heterogeneity of tissue macrophages is unravelling, as
are their diverse contributions to physiology and pathophysiology. Moreover, also given …

Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis
causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and …

Sepsis is a systemic response to infection with life-threatening consequences. Our
understanding of the molecular and cellular impact of sepsis across organs remains …

Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …

Microglial reactivity to injury and disease is emerging as a heterogeneous, dynamic, and
crucial determinant in neurological disorders. However, the plasticity and fate of disease …

Molecular pathways mediating systemic inflammation entering the brain parenchyma to
induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in …

Glaucoma is the second leading cause of blindness worldwide, affecting~ 80 million people
by 2020 (,). The condition is characterized by a progressive loss of retinal ganglion cells …