Synthetic biology to access and expand nature's chemical diversity
Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …
complex molecules with diverse applications, from medicine to agriculture and materials …
Engineering metabolism through dynamic control
N Venayak, N Anesiadis, WR Cluett… - Current opinion in …, 2015 - Elsevier
Highlights•Synthetic biology provides new tools for the dynamic control of
metabolism.•Dynamic control is crucial to further the field of metabolic engineering.•Sensors …
metabolism.•Dynamic control is crucial to further the field of metabolic engineering.•Sensors …
Personal and in-store factors influencing impulse buying behavior among generation Y consumers of small cities
For decades, impulse buying is considered to be one of the significant factors to increase
sales volume in the retail sector. Past studies have investigated the impulsive buying …
sales volume in the retail sector. Past studies have investigated the impulsive buying …
Sequential control of biosynthetic pathways for balanced utilization of metabolic intermediates in Saccharomyces cerevisiae
W Xie, L Ye, X Lv, H Xu, H Yu - Metabolic engineering, 2015 - Elsevier
Balanced utilization of metabolic intermediates and controllable expression of genes in
biosynthetic pathways are key issues for the effective production of value-added chemicals …
biosynthetic pathways are key issues for the effective production of value-added chemicals …
Programmable biomolecular switches for rewiring flux in Escherichia coli
Synthetic biology aims to develop programmable tools to perform complex functions such as
redistributing metabolic flux in industrial microorganisms. However, development of protein …
redistributing metabolic flux in industrial microorganisms. However, development of protein …
Metabolic pathway balancing and its role in the production of biofuels and chemicals
Highlights•Rational and modern approaches for metabolic pathway engineering.•Tailor-
made cell factories for biofuel and value-added chemical production.•Synthetic and systems …
made cell factories for biofuel and value-added chemical production.•Synthetic and systems …
Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products
Malonyl-CoA is the building block for fatty acid biosynthesis and also a precursor to various
pharmaceutically and industrially valuable molecules, such as polyketides and biopolymers …
pharmaceutically and industrially valuable molecules, such as polyketides and biopolymers …
Dynamic metabolic engineering: new strategies for developing responsive cell factories
IM Brockman, KLJ Prather - Biotechnology journal, 2015 - Wiley Online Library
Metabolic engineering strategies have enabled improvements in yield and titer for a variety
of valuable small molecules produced naturally in microorganisms, as well as those …
of valuable small molecules produced naturally in microorganisms, as well as those …
Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch
Y Soma, K Tsuruno, M Wada, A Yokota, T Hanai - Metabolic engineering, 2014 - Elsevier
Overexpression of genes in production pathways and permanent knockout of genes in
competing pathways are often employed to improve production titer and yield in metabolic …
competing pathways are often employed to improve production titer and yield in metabolic …
Dynamic knockdown of E. coli central metabolism for redirecting fluxes of primary metabolites
IM Brockman, KLJ Prather - Metabolic engineering, 2015 - Elsevier
Control of native enzyme levels is important when optimizing strains for overproduction of
heterologous compounds. However, for many central metabolic enzymes, static knockdown …
heterologous compounds. However, for many central metabolic enzymes, static knockdown …