Synthetic biology to access and expand nature's chemical diversity

MJ Smanski, H Zhou, J Claesen, B Shen… - Nature Reviews …, 2016 - nature.com
Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

Engineering metabolism through dynamic control

N Venayak, N Anesiadis, WR Cluett… - Current opinion in …, 2015 - Elsevier
Highlights•Synthetic biology provides new tools for the dynamic control of
metabolism.•Dynamic control is crucial to further the field of metabolic engineering.•Sensors …

Personal and in-store factors influencing impulse buying behavior among generation Y consumers of small cities

M Husnain, B Rehman, F Syed… - Business Perspectives …, 2019 - journals.sagepub.com
For decades, impulse buying is considered to be one of the significant factors to increase
sales volume in the retail sector. Past studies have investigated the impulsive buying …

Sequential control of biosynthetic pathways for balanced utilization of metabolic intermediates in Saccharomyces cerevisiae

W Xie, L Ye, X Lv, H Xu, H Yu - Metabolic engineering, 2015 - Elsevier
Balanced utilization of metabolic intermediates and controllable expression of genes in
biosynthetic pathways are key issues for the effective production of value-added chemicals …

Programmable biomolecular switches for rewiring flux in Escherichia coli

C Gao, J Hou, P Xu, L Guo, X Chen, G Hu, C Ye… - Nature …, 2019 - nature.com
Synthetic biology aims to develop programmable tools to perform complex functions such as
redistributing metabolic flux in industrial microorganisms. However, development of protein …

Metabolic pathway balancing and its role in the production of biofuels and chemicals

JA Jones, ÖD Toparlak, MAG Koffas - Current opinion in biotechnology, 2015 - Elsevier
Highlights•Rational and modern approaches for metabolic pathway engineering.•Tailor-
made cell factories for biofuel and value-added chemical production.•Synthetic and systems …

Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products

Y Yang, Y Lin, L Li, RJ Linhardt, Y Yan - Metabolic engineering, 2015 - Elsevier
Malonyl-CoA is the building block for fatty acid biosynthesis and also a precursor to various
pharmaceutically and industrially valuable molecules, such as polyketides and biopolymers …

Dynamic metabolic engineering: new strategies for developing responsive cell factories

IM Brockman, KLJ Prather - Biotechnology journal, 2015 - Wiley Online Library
Metabolic engineering strategies have enabled improvements in yield and titer for a variety
of valuable small molecules produced naturally in microorganisms, as well as those …

Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch

Y Soma, K Tsuruno, M Wada, A Yokota, T Hanai - Metabolic engineering, 2014 - Elsevier
Overexpression of genes in production pathways and permanent knockout of genes in
competing pathways are often employed to improve production titer and yield in metabolic …

Dynamic knockdown of E. coli central metabolism for redirecting fluxes of primary metabolites

IM Brockman, KLJ Prather - Metabolic engineering, 2015 - Elsevier
Control of native enzyme levels is important when optimizing strains for overproduction of
heterologous compounds. However, for many central metabolic enzymes, static knockdown …