[PDF][PDF] Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
D Liebschner, PV Afonine, ML Baker… - … Section D: Structural …, 2019 - journals.iucr.org
Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods
to determine three-dimensional macromolecular structures, which are required to …
to determine three-dimensional macromolecular structures, which are required to …
Protein structure prediction: conventional and deep learning perspectives
VA Jisna, PB Jayaraj - The protein journal, 2021 - Springer
Protein structure prediction is a way to bridge the sequence-structure gap, one of the main
challenges in computational biology and chemistry. Predicting any protein's accurate …
challenges in computational biology and chemistry. Predicting any protein's accurate …
Stilbene-based natural compounds as promising drug candidates against COVID-19
The pandemic coronavirus disease (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) presents a great threat to public health. Currently …
syndrome coronavirus 2 (SARS-CoV-2) presents a great threat to public health. Currently …
Computational investigation on Andrographis paniculata phytochemicals to evaluate their potency against SARS-CoV-2 in comparison to known antiviral compounds …
NA Murugan, CJ Pandian… - Journal of Biomolecular …, 2021 - Taylor & Francis
The outbreak due to SARS-CoV-2 (or Covid-19) is spreading alarmingly and number of
deaths due to infection is aggressively increasing every day. Due to the rapid human to …
deaths due to infection is aggressively increasing every day. Due to the rapid human to …
[HTML][HTML] Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma
Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss-
of-function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by …
of-function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by …
Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design
An optimal HIV vaccine should induce broadly neutralizing antibodies (bnAbs) that
neutralize diverse viral strains and subtypes. However, potent bnAbs develop in only a small …
neutralize diverse viral strains and subtypes. However, potent bnAbs develop in only a small …
Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
O Khersonsky, D Röthlisberger, AM Wollacott… - Journal of molecular …, 2011 - Elsevier
Although de novo computational enzyme design has been shown to be feasible, the field is
still in its infancy: the kinetic parameters of designed enzymes are still orders of magnitude …
still in its infancy: the kinetic parameters of designed enzymes are still orders of magnitude …
PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period
Summary PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a
phosphoswitch that controls PER stability and repressive activity in the molecular clock …
phosphoswitch that controls PER stability and repressive activity in the molecular clock …
Fully blind peptide-protein docking with pepATTRACT
Peptide-protein interactions are ubiquitous in the cell and form an important part of the
interactome. Computational docking methods can complement experimental …
interactome. Computational docking methods can complement experimental …
Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors
MR Dent, I López-Duarte, CJ Dickson… - Physical Chemistry …, 2015 - pubs.rsc.org
In order to fully understand the dynamics of processes within biological lipid membranes, it
is necessary to possess an intimate knowledge of the physical state and ordering of lipids …
is necessary to possess an intimate knowledge of the physical state and ordering of lipids …