As one of the major therapeutic options for cancer treatment, chemotherapy has limited
selectivity against cancer cells. Consequently, this therapeutic strategy offers a small …

Formation of distant metastases is by far the most common cause of cancer-related deaths.
The process of metastasis formation is complex, and within this complex process the …

Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert
their functions in many biological processes, their potential involvement in cytoplasmic …

Integrins are cell adhesion receptors, which are typically transmembrane glycoproteins that
connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical …

Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by
aggressive behavior, high risk of distant recurrence, and poor survival. Chemotherapy is still …

The Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple
fundamental cellular signaling cascades. Nrp family members have key functions in VEGF …

In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB
(glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with …

Tumor–stroma interactions significantly influence cancer cell metastasis and disease
progression. These interactions are partly comprised of the cross-talk between tumor and …

Background Neuroinflammation is one of the hallmarks of neurodegenerative diseases,
such as Parkinson's disease (PD). Activation of glial cells, including microglia and …

Breast cancer is a heterogeneous group of malignancies with a spectrum of molecular
subtypes, pathologies and outcomes that together comprise the most common non …