Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

Uric acid is the end product of purine metabolism in humans, and its excessive accumulation
leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys …

Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the
development of hypertension and chronic kidney disease. A 2-hit model has been proposed …

Asymptomatic hyperuricemia is frequently observed in patients with kidney disease.
Although a substantial number of epidemiologic studies have suggested that an elevated …

Autophagy is a cell self-renewal process that relies on the degradation of the cytoplasmic
proteins or organelles of lysosomes and is associated with development of numerous …

Excessive consumption of fat and sugar is associated with various chronic diseases.
However, the variation of fat and sugar content in the diet greatly affected the outcome. In …

Abstract Ethnopharmacological relevance Simiao Pills, a classical traditional Chinese
medicine prescription recorded in Cheng Fang Bian Du, has been traditionally used to treat …

Though the pathogenesis of hyperuricemia-induced renal complications is not precisely
known, hyperuricemia has been recognized as an independent risk factor for renal disease …

Chronic kidney disease (CKD) is defined by gradual deterioration of the renal parenchyma
and decline of functioning nephrons. CKD is now recognized as a distinct risk factor for …

Renal fibrosis is relentlessly progressive and irreversible, and a life-threatening risk. With
the continuous intake of a high-purine diet, hyperuricemia has become a health risk factor in …