The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is
hijacked in many pathological conditions. This affects MHC class I levels and peptide …

Within cells, proteins can co-assemble into functionally integrated and spatially restricted
multicomponent complexes. Often, the affinities between individual proteins are relatively …

R-loops are three-stranded nucleic acid structures that accumulate on chromatin in
neurological diseases and cancers and contribute to genome instability. Using a proximity …

Studying protein–protein interactions (PPIs) is useful for understanding cellular functions
and mechanisms. Evaluating these PPIs under conditions as similar as possible to native …

In living systems, a complex network of protein-protein interactions (PPIs) underlies most
biochemical events. The human protein-protein interactome has been surveyed using yeast …

Fanconi anemia (FA) is a disease of DNA repair characterized by bone marrow failure and a
reduced ability to remove DNA interstrand cross-links. Here, we provide evidence that the …

Proteins perform biochemical functions by forming complexes, or protein–protein
interactions (PPIs). Many different approaches such as phage display, yeast hybridization …

Long noncoding RNAs (lncRNAs) are transcripts that do not code for proteins, but
nevertheless exert regulatory effects on various biochemical pathways, in part via …

The identification of new RNA functions and the functional annotation of transcripts in
genomes represent exciting yet challenging endeavours of modern biology. Crucial insights …

Proteinaceous nanovaccine delivery systems have significantly promoted the development
of various high-efficiency vaccines. However, the widely used method of coupling the …